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Pharmacokinetics of temocapril and temocaprilat after 14 once daily oral doses of temocapril in hypertensive patients with varying degrees of renal impairment

机译：替莫卡普利和替莫卡普利特在每天14次口服替莫卡普利口服治疗不同程度肾功能不全的高血压患者中的药代动力学

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Aims The aim of this study was to determine the potential influence of renal impairment on the pharmacokinetics of temocapril and its pharmacologically active diacid metabolite, temocaprilat.

机译：目的：本研究的目的是确定肾脏损害对替莫卡普利及其药理活性二酸代谢产物替莫卡普利拉的药代动力学的潜在影响。

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作者
Püchler, K.; Eckl, K. M.; Fritsche, L.; Renneisen, K.; Neumayer, H.-H.; Sierakowski, B.; Lavrijssen, A. T. J.; Thomsen, T.; Roots, I.;
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年度 2003
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专利

1. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. [J] . Puchler K, Sierakowski B, Roots I British Journal of Clinical Pharmacology . 1998,第4期

机译：替莫卡普利和替莫卡普利特在老年和老年高血压患者中的单剂量和稳态药代动力学。
2. Pharmacokinetics and Safety of a Single Oral Dose of Mirogabalin in Japanese Subjects With Varying Degrees of Renal Impairment [J] . Kato Manabu, Tajima Naoyuki, Shimizu Takako, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2018,第1期

机译：日本科目中单次口服剂量的麦考蛋白的药代动力学和安全性，具有不同程度的肾损伤
3. Pharmacokinetics of a Single Oral Dose of the MEK1/2 Inhibitor Selumetinib in Subjects With End-Stage Renal Disease or Varying Degrees of Hepatic Impairment Compared With Healthy Subjects [J] . Dymond Angela W., Martin Paul, So Karen, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2017,第5期

机译：与健康受试者相比，单次口服剂量的Mek1 / 2抑制剂Selumetinib的单次口服剂量的Mek1 / 2抑制剂Selumetinib或不同程度的肝障碍程度
4. Design evaluation for pharmacokinetic studies in patients with renal impairment [D] . Liu, Jin 2007

机译：肾功能不全患者药代动力学研究的设计评估
5. Pharmacokinetics of temocapril and temocaprilat after 14 once daily oral doses of temocapril in hypertensive patients with varying degrees of renal impairment [O] . K. Püchler, K. M. Eckl, L. Fritsche, 1997

机译：替莫卡普利和替莫卡普利的每日14次口服替莫卡普利口服治疗不同程度的肾功能不全的高血压患者的药代动力学
6. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients [O] . Püchler, K, Sierakowski, B, Roots, I 1998

机译：替莫卡普利和替莫卡普利特在老年和老年高血压患者中的单剂量和稳态药代动力学
7. Guidance for Industry. Pharmacokinetics in Patients with Impaired Renal Function211 Study Design, Data Analysis, and Impact on Dosing and Labeling [R] . 1998

机译：工业指南。肾功能受损患者的药代动力学211研究设计，数据分析以及对剂量和标记的影响

Pharmacokinetics of temocapril and temocaprilat after 14 once daily oral doses of temocapril in hypertensive patients with varying degrees of renal impairment

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